Biopharma process plant GMP plasma

Brinox

Condition: excellent (used), Year of construction: 2018, Brinox SVMHI-550 Sterile Hold Vessel 550L 316L Stainless Steel Year 2018 Ncjdpjymymvsfx Ahwsn Test Pressure 7.2 Bar Very little use. Tanks are in excellent condition.

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Package 15 PP6715 – CS6715 Brinox LEP 11 – Pharma Chromatography and CIP System Ncedpfx Ajyl Rqpehwsn New – original packaging – Factory New Manufacturer: Brinox Model: LEP 11 Version: PP6715 with CIP System CS6715 Condition: New, unused, original packaging Description For sale is a high-quality pharmaceutical chromatography system Brinox LEP 11, consisting of the PP6715 control panel and the corresponding CS6715 CIP unit. The system is completely new, unused, and in the manufacturer's original condition. It was designed for industrial C1-INH chromatography and meets the highest GMP standards. Scope of Functions - Slurry transfer - Washing and elution processes - Transfer to pre-precipitation tanks - Gel disposal - Independent CIP loop Technical Features - Product-contacting components in stainless steel 1.4435 - Electropolished, Ra ≤ 0.8 µm - FDA-compliant sealing systems - CIP/SIP-capable - Operating pressure up to 6 bar - Temperature range up to 95°C - Fully drainable piping CIP Skid CS6715 - Stainless steel frame - Centrifugal pump - Shell-and-tube heat exchanger - Temperature control of cleaning media - Adjustable feed pressure The system is in factory-new condition with zero operating hours.

Year of construction: 2020, condition: new, functionality: fully functional, Equipment: documentation/manual, Package 14 PP6713 – CS6713 Brinox LEP 11 – GMP Chromatography System with CIP Skid New – unused – in original packaging Manufacturer: Brinox Model: LEP 11 Version: PP6713 with CIP System CS6713 Condition: New – in original packaging – never installed Description Offered is a pharmaceutical chromatography system LEP 11, consisting of the chromatography panel PP6713 and the corresponding CIP skid CS6713. The system is completely new, unused, and remains in the manufacturer’s original condition. The unit was designed for GMP-grade protein purification as part of C1-INH chromatography. System Features Cleanroom panel for wall integration Transfer lines to sieve-bottom tanks Precipitation vessel connection Gel waste disposal line Complete utility/process piping Technical Specifications Design pressure: –0.9 to +6 bar Design temperature: +2 to +95 °C Ncsdpfx Aeyl Rnnehwjn Electropolished surfaces Ra ≤ 0.8 µm Material: 1.4435 stainless steel Fully drainable GMP-compliant design CIP System CS6713 Stainless steel frame construction Centrifugal pump Shell-and-tube heat exchanger Conductivity, pressure, and temperature monitoring Adjustable CIP supply flow The system is brand new and has never been in operation.

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Brinox LEP 11 – Pharmaceutical Chromatography System with CIP Unit New, unused, original packaging Manufacturer: Brinox Model: LEP 11 Version: PP6711 with associated CIP unit CS6711 Condition: New – unused – original packaging (Factory New Condition) Njdpsyl Ndnjfx Ahwscn Description For sale is a Brinox LEP 11 pharmaceutical chromatography system, consisting of the chromatography panel PP6711 and the associated CIP unit CS6711. The system is completely new, unused, and in its original packaging. It was designed, manufactured, and delivered, but has never been installed or put into operation. This unit is designed for C1-INH chromatography and is used for controlled protein purification using sieve-bottom vessels in a GMP environment. Process Functions • Transfer of loaded QAE resin (slurry) • Washing and elution processes • Transfer of eluate to pre-precipitation vessel • Gel disposal via container station • Fully automatic CIP and SIP cleaning Technical Data • Fully CIP and SIP capable • Design pressure: –0.9 to +6 bar • Design temperature: +2°C to +95°C • Flow rate up to 10 m³/h • Adjustable slurry transfer 0.2 – 3 m³/h Design Features • Product-contact parts made of stainless steel 1.4435 • Electropolished Ra ≤ 0.8 µm • FDA and EU-compliant seals • Drainable construction • Cleanroom panel with tri-clamp connection points • Magnetically monitored transfer arcs • 0.2 µm vent filter CIP Unit CS6711 • Compact stainless steel skid • Centrifugal pump • Shell-and-tube heat exchanger • Adjustable operating pressure • GMP-compliant design The system is in factory-new condition and has never been used in production.

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, BRINOX LEP13.2 – AS Storage Tempering Unit – GMP – Year of Manufacture 2020 – Like New Manufacturer: BRINOX Process Systems LEP13.2 KK6772 Package 12 System type: LEP13.2 – AS Storage Tempering Unit Project: Ammonium sulphate system Year of manufacture: 2020 Serial number: 1003624 Tag number: MR-ASF-ASF61-KK6772 Location: Germany DESCRIPTION For sale is a nearly new LEP13.2 tempering unit in pharmaceutical GMP-compliant design, manufactured by BRINOX Process Systems. The unit is constructed as a compact, pre-assembled skid unit and was designed for use in an ammonium sulphate storage system. Complete project and FAT documentation is available. TECHNICAL DATA Type: LEP13.2 – AS Storage Tempering Unit Medium: Ammonium sulphate Design: Pharma / GMP Materials: Stainless steel 1.4435 / 1.4301 Control air pressure: 6 bar Pressure and leak testing performed FAT successfully completed MAIN COMPONENTS 2x KSB Movitec centrifugal pumps Alfa Laval plate heat exchanger Electric instantaneous water heater Reflex expansion vessel Samson control valve GEMÜ ball valves (manual & pneumatic) Labom pressure gauges Comprehensive sensors & measuring instruments Insulated pipework Stainless steel skid frame construction APPLICATIONS Temperature control of process media Use in GMP-regulated production areas Pharmaceutical and biotechnology plants Media circuits with temperature control CONSTRUCTION Compact, closed skid unit Fully piped Professionally insulated piping High-quality industrial components Service-friendly layout Completely dismountable and transportable CONDITION Condition: New, original packaging Year of manufacture: 2020 Project-specific unit Hardly any operating hours Visually and technically in excellent condition Nodpfx Ahjyl Na Nswscn DOCUMENTATION FAT documentation Pressure test certificates P&ID diagrams Layout drawings Factory certificates according to EN10204 Materials lists EU declarations of conformity FEATURES Complete GMP documentation High-quality brand components Ideal for pharmaceutical and biotech applications Immediately available Significantly below new price

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Manufacturer: BRINOX Process Systems LEP13.2 KK6771 Package 11 System type: Temperature Control Unit – LEP13.2 AS Storage Project: Ammonium Sulfate Supply and Disposal Unit: KK6771 Year of manufacture: 2020 Serial number: 1003622 Equipment number: 20022749 LEP13.2 – AS Storage Temperature Control Unit TECHNICAL DATA Product: LEP13.2 – AS Storage Temperature Control Unit Medium: Ammonium sulfate Design: Pharmaceutical / GMP Product-contact materials: 1.4435 / 1.4301 stainless steel Dimensions (L x W x H): approx. 1900 x 1545 x 1580 mm Control air supply: 6 bar (AIP) Tested pressure range: up to approx. 3–4 bar (Leak test documented) MAIN COMPONENTS 2x centrifugal pumps Horizontal shell-and-tube heat exchanger Electric flow heater Expansion vessel Pressure and temperature measurement points Pneumatic control valves Manual ball valves (GEMÜ) Stainless steel control cabinet / terminal box Fully insulated piping APPLICATION The temperature control unit is used for precise temperature regulation in the ammonium sulfate storage system of a pharmaceutical production facility. Suitable for: - Pharmaceutical production environments - GMP-regulated systems - Media temperature control systems - Turn-over package integration DESIGN / CONSTRUCTION - Complete, pre-assembled skid unit - Stainless steel frame construction - Compact design with unobstructed maintenance access - Fully piped and insulated - Clear labeling of all measuring points and fittings - Pharmaceutical-grade execution as per CSL Behring customer specification - P&ID checked - Layout checked - Multiple documented leak tests - Calibrated measuring devices with certificates The system is fully assembled and prepared for seamless integration into existing pharmaceutical installations. CONDITION - As-new / Project system - Year of manufacture: 2020 - FAT completed - Pressure test passed - Complete documentation available COMPREHENSIVE DOCUMENTATION Includes, among others: - Factory certificates according to EN 10204 - Material lists - EU declarations - Inspection reports - Documentation of installed equipment - I&C documentation - As-built isometrics - User manual - Calibration certificates SPECIAL FEATURES - Project-specific pharmaceutical design - GMP-compliant manufacturing - Complete skid-mounted construction - Compact footprint (approx. 1.9 x 1.5 m) - Maintenance-friendly layout - High-quality piping insulation Nodsyl I S Djpfx Ahwjcn - Ideal for technical areas close to cleanrooms

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Manufacturer: BRINOX Product: LEP13.1 – AS-Batch Temperature Control Unit System type: Temperature control unit for ammonium sulfate batch system Year of manufacture: 2020 Serial number: 1003620 Tag number: MR-ASF-ASF61-KK6770 Equipment number: 20022748 Media Connections / Process Data WCOV – Chilled water supply: 6 °C WCOR – Chilled water return: 12 °C WSV – Process/municipal water AIP10 – Control compressed air 6 bar Design as a closed temperature control module with integrated pump and heat exchanger technology. Dimensions Overall dimensions as per layout: approx. 1920 x 1435 x 1573 mm (L x W x H) Compact, skid-mounted unit with welded stainless steel frame. Construction Frame construction in stainless steel Fully insulated piping (industrial insulation) Stainless steel shell-and-tube heat exchanger Electrical inline water heater WT1011 Pump PU1021 Pump PU9203 Heat exchanger WT1001 Expansion vessel BH9701 Fittings: GEMÜ shut-off valves Pneumatically actuated valves Manual ball valves Pressure gauges Sensors and instrumentation as per P&ID Complete piping and component labeling provided. Condition New and in original packaging. Not yet put into operation in production. Factory new condition. Supplied directly by the manufacturer Brinox. FAT / Test Status FAT carried out. Leak test: Test medium: Compressed air Nedpfxsyl Izxo Ahwocn Test pressure: approx. 3 bar Holding time: 1 hour Result: Passed Calibration: Pressure gauge calibrated Measuring range: 0–10 bar Calibration certificate available Traceable to national standards Documentation Turn-Over-Package complete Included documents: FAT plan FAT report Non-conformance form Layout drawing check Maintenance and calibration accessibility check P&ID review Leak test report Calibration certificates Documentation check Factory certificate 2.1 according to EN 10204 LBM material list incl. EU declarations List of installed components – equipment List of installed components – instrumentation points (PLT) Material parts list for as-built isometry Key Features GMP-compliant construction Pharma/biotech project quality Full traceability Compact plug-and-play skid design Completely piped, insulated, and ready to connect Immediately available

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Manufacturer BRINOX d.o.o. Project Number B-0001113-LEP2.3 LEP 2.3 KK6762 Package 9 Module M024 Product Description LEP2.3 – Wash Solution Temperature Control Unit Serial Number 1003572 Equipment Number 20022782 Tag Number MR-INH-VPR61-KK6762 Year of Manufacture 2020 Technical Data System Type Pharma temperature control skid for precise temperature regulation of wash and elution solutions. Constructed as a compact, multi-level stainless steel frame design with fully integrated pump, heat exchanger, and valve technology. Dimensions Length 1920 mm Width 1365 mm Height 1840 mm Design Fully pre-assembled, insulated temperature control skid Pharmaceutical design according to GMP requirements Industrial stainless steel frame construction Materials Product-contact parts: Stainless steel 1.4435 / 1.4571 Frame construction: Stainless steel 1.4301 Welds as per EN ISO 13920 D Insulation Completely insulated piping and equipment Closed-cell high-performance insulation with black protective sheathing Main Components PU1021 Process Pump PU9203 Chilled Medium Pump WT1001 Plate Heat Exchanger WT1011 Finned Tube Heat Exchanger BH9701 Expansion Tank Pneumatic Control Valves GEMÜ Stainless Steel Ball Valves Pressure Transmitters Temperature Measurement Points Pressure Gauges Electrical Junction Box with Warning Labels Stainless Steel Cable Trays Media Chilled Brine Supply / Return Wash Solution Process Medium Control Air 6 bar All media connections sealed at factory and packaged securely for transport. Leak Testing Performed as pressure test with compressed air. DP-01 Medium: Compressed Air Test Pressure: 3.15 bar Pressure Drop: 0.13 bar Date: 27.07.2020 Result: Passed DP-02 Medium: Compressed Air Test Pressure: 3.28 bar Pressure Drop: 0.07 bar Date: 26.07.2020 Result: Passed Pressure holding time: 1 hour each No leaks detected Calibration Certificates Calibration Laboratory: LOTRIČ Metrology Certificates according to EN ISO/IEC 17025 Measurement Ranges: –1 to 20 bar and 0 to 10 bar Calibration performed Documentation Scope FAT Plan and Report Deviation Report Layout Drawing Check Maintenance Inspection P&ID Leak Test Report Calibration Certificates Works Certificate 2.1 EN10204 Material List As-Built Isometrics Complete Turn-Over Package Inspection Status FAT performed Pressure test passed Njdsyl Iwtspfx Ahwjcn Calibrations available PED-compliant design Pharma documentation complete Application Temperature control of wash and elution solutions in biopharmaceutical production facilities Suitable for GMP environments Condition New system Original packaging Unused Year of manufacture: 2020 Factory condition Fully documented Immediately available

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Manufacturer: BRINOX Type: LEP2.3 – Wash Solution Temperature Control Unit Year of Manufacture: 2020 Serial Number: 1003507 LEP2.3 KK6761 Package 8 Tag No.: MR-INH-VPR61-KK6761 Equipment No.: 20023781 Nsdpfx Ahjyl It Iswecn Technical Data System Type: Temperature control unit / heating and cooling module for wash solution (CIP or process washing system) Design: Compact, fully pre-assembled skid unit in robust stainless steel frame construction, crane-liftable via integrated lifting points. Frame and Construction: Welded stainless steel construction in industrial design, free-standing, multi-level piping configuration for optimal space utilization. Maintenance-friendly access from multiple sides. Integrated cable trays. Piping: Stainless steel process piping in hygienic design, welded and partially flanged. Multilayer thermal insulation of main lines and apparatus. Integrated drain and vent fittings. Valve Technology: Multiple manual ball valves (GEMÜ) in main and bypass circuits. Pneumatically actuated control and shut-off valves for automatic temperature regulation. Diaphragm and control valves integrated in the heating and cooling circuit. Instrumentation and Control: Temperature measurement points in both supply and return lines. Pressure sensors in the process section. Integrated flow measurement. Electrical junction box with protective labeling. Automatic temperature control via pneumatic control valve. Heat Exchanger: Cylindrical stainless steel heat exchanger, insulated and integrated into the piping system. Designed for controlled heating and/or cooling of the wash solution in a closed loop. Pump Technology: Two electrically driven centrifugal pumps with red-painted motors for process recirculation within the temperature control unit. Electrical: Electrical junction box with warning markings. Wired sensors and actuators. Prepared for integration into a central PLC or process control system. Application This system is used for precise temperature regulation of a wash solution within a pharmaceutical or biotechnological process system. Typical areas of application include CIP systems, production plant washing stations, and temperature-controlled cleaning processes in the pharmaceutical and biotechnology sectors. The wash solution circulates in a closed loop via pumps, is temperature controlled by the integrated heat exchanger, and continuously monitored by sensors. Temperature is regulated automatically via pneumatic control valves to maintain defined setpoints accurately. Construction Compact modular skid design with fully insulated main lines. Stainless steel surfaces in hygienic industrial finish. Clearly organized media routing and structured piping layout. Crane-transportable via integrated lifting points. Condition Year of manufacture 2020. Very good visual and technical condition. Professional execution in pharmaceutical plant engineering. FAT / Documentation Typically supplied with CE conformity, Factory Acceptance Test (FAT), and technical documentation including P&ID diagrams and material certificates for product-contacting components. Special Features Fully insulated temperature control module in a compact, high power density design. High-quality valve technology (GEMÜ). Multiple integrated measurement and control points. Suitable for validated pharmaceutical processes. Industrial, pre-assembled skid solution with clearly structured media routing.

Condition: new, Year of construction: 2020, functionality: fully functional, Equipment: documentation/manual, Manufacturer: BRINOX Process Systems Type: LEP 2.3 System Type: Temperature Control Unit for Washing and Elution Solutions Year of Manufacture: 2020 Serial Number: 1003563 Device Number: KK6752 Design: Stainless Steel Skid, Pharmaceutical Construction LEP 2.3 KK6752 Package 7 Technical Data Design: Compact, pre-assembled temperature control unit on a welded stainless steel frame (skid system) Materials: Product-contact: Stainless Steel 1.4435 / 1.4404 Non-product contact: Stainless Steel 1.4301 Piping System: Orbital welding (pharmaceutical grade) Fully welded construction As-built isometric drawing available Pressure Data: Leak test using compressed air Test pressure: 3.37 bar Holding time: 1 hour Result: Leak-free Measurement and Control Technology: Pressure measurement (PIR, PI, PIRC) Temperature measurement (TI, TIRC) Level measurement (limit) Flow monitoring Position feedback Motor control On/Off pneumatic valves Pressure sensor measuring range: 0–10 bar Electrical Connection: Control air: 6 bar Ncsdpfx Ahjyl Ipcewsn Automation-capable (PLT nodes fully documented) Main Components: 2 process pumps Plate heat exchanger Finned tube heat exchanger Expansion vessel Multiple hygienic control and shut-off valves Integrated instrumentation units Cooling Medium: Chilled brine (supply/return interfaces available) ───── Dimensions / Weight Construction: Compact skid unit Industrial design for cleanroom/technical areas (Transport and installation dimensions as per layout drawing) Application Area Temperature control of: Washing solutions Elution solutions Process media in biopharmaceutical environments Fields of Application: Biotechnology Plasma fractionation GMP production facilities Build / Construction Welded stainless steel frame Low-vibration pump mounting Hygienic piping Full implementation according to P&ID Clear separation between product and non-product areas Service and maintenance access tested Mechanical SAT-IQ test performed Metrological SAT-IQ test performed P&ID diagram check completed Layout drawing check completed Condition Manufactured in 2020 Industrial and pharmaceutical version New, original packaging Pressure tested Sensors calibrated FAT performed FAT / Documentation Available: FAT plan and report Deviation management Layout check P&ID check Leak test Sensor calibration Service and accessibility inspection EN10204 factory certificate Material lists (LBM) As-built isometry Component lists (equipment & PLT nodes) Special Features Pharma-GMP compliant design Complete validation documentation Full traceability Certified pressure testing Calibration certificates from accredited laboratories High-quality plant construction by BRINOX High-end biopharma standard